Papers/PMID:19066368
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.
JAMA2009The record
6 findings · 1 compound · 6 endpoints · 6 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
6 findings
α-tocopherol — no detected effect on prostate cancer incidence
Evidence strength: moderate.FindingNull resultreplicated ×3“There was no effect of vitamin E on prostate cancer incidence (HR, 0.97; 95% CI, 0.85–1.09; P=0.58) (Table 2).”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently
Effect 0.97 hazard ratio, 95% CI 0.85 to 1.09
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink
α-tocopherol — no detected effect on colorectal cancer incidence
Evidence strength: moderate.FindingNull resultreplicated ×2“We found no effect for any site-specific cancers, including colorectal (HR, 0.88; 95% CI, 0.64–1.19; P=0.40), lung (HR, 0.89; 95% CI, 0.60–1.31; P= 0.55), bladder (HR, 1.21; 95% CI, 0.76–1.94; P=0.43), and pancreatic (HR, 1.14; 95% CI, 0.67–1.93; P=0.63) cancer.”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently
Effect 0.88 hazard ratio, 95% CI 0.64 to 1.19
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink
α-tocopherol — no detected effect on urinary bladder cancer incidence
Evidence strength: moderate.FindingNull resultreplicated ×1“We found no effect for any site-specific cancers, including colorectal (HR, 0.88; 95% CI, 0.64–1.19; P=0.40), lung (HR, 0.89; 95% CI, 0.60–1.31; P= 0.55), bladder (HR, 1.21; 95% CI, 0.76–1.94; P=0.43), and pancreatic (HR, 1.14; 95% CI, 0.67–1.93; P=0.63) cancer.”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently
Effect 1.21 hazard ratio, 95% CI 0.76 to 1.94
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink
α-tocopherol — no detected effect on all-cause mortality
Evidence strength: moderate.FindingNull resultreplicated ×4“In addition, there was no significant effect of vitamin E on total mortality (HR, 1.08; 95% CI, 0.98–1.19; P=0.13) or cancer mortality (HR, 1.13; 95% CI, 0.95–1.34; P=0.16).”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently; mean follow-up 8.0 years
Effect 1.08 hazard ratio, 95% CI 0.98 to 1.19
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink
α-tocopherol — no detected effect on lung cancer incidence
Evidence strength: limited.FindingNull result“We found no effect for any site-specific cancers, including colorectal (HR, 0.88; 95% CI, 0.64–1.19; P=0.40), lung (HR, 0.89; 95% CI, 0.60–1.31; P= 0.55), bladder (HR, 1.21; 95% CI, 0.76–1.94; P=0.43), and pancreatic (HR, 1.14; 95% CI, 0.67–1.93; P=0.63) cancer.”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently
Effect 0.89 hazard ratio, 95% CI 0.6 to 1.31
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink
α-tocopherol — no detected effect on pancreatic cancer incidence
Evidence strength: limited.FindingNull result“We found no effect for any site-specific cancers, including colorectal (HR, 0.88; 95% CI, 0.64–1.19; P=0.40), lung (HR, 0.89; 95% CI, 0.60–1.31; P= 0.55), bladder (HR, 1.21; 95% CI, 0.76–1.94; P=0.43), and pancreatic (HR, 1.14; 95% CI, 0.67–1.93; P=0.63) cancer.”
Quoted verbatim from Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 400 IU synthetic alpha-tocopherol on alternate days
- Population
- 14,641 male US physicians aged 50 or older; 2x2x2x2 factorial, with vitamin C, multivitamin and beta carotene randomised independently
Effect 1.14 hazard ratio, 95% CI 0.67 to 1.93
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.2009PMID:1906636810.1001/jama.2008.862Industry fundedPermalink