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Proteins/UNIPROT:P61081
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation..
Function from UniProtKB (P61081), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
86 statements
86 statements · 3 reference databases · Subject: UBE2M · Sources: gene ontology, Hetionet, Reactome
1 reaction
3 names
Resolves to: UBE2M
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data