Proteins/UNIPROT:Q9BTE7

DCUN1D5

ProteinUNIPROT:Q9BTE7

Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth..

Function from UniProtKB (Q9BTE7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: DCUN1D5 · Sources: gene ontology, Hetionet, Reactome

Order

SSC5D covaries with DCUN1D5ProteinHetionet hetionet:covaries:284297-84259Inferred only
CUL1 interacts with DCUN1D5ProteinHetionet hetionet:interacts:84259-8454Inferred only
CUL2 interacts with DCUN1D5ProteinHetionet hetionet:interacts:84259-8453Inferred only
CUL3 interacts with DCUN1D5ProteinHetionet hetionet:interacts:84259-8452Inferred only
CUL4A interacts with DCUN1D5ProteinHetionet hetionet:interacts:84259-8451Inferred only
CUL5 interacts with DCUN1D5ProteinHetionet hetionet:interacts:8065-84259Inferred only
RCHY1 interacts with DCUN1D5ProteinHetionet hetionet:interacts:25898-84259Inferred only
SUMO2 interacts with DCUN1D5ProteinHetionet hetionet:interacts:6613-84259Inferred only
UBC interacts with DCUN1D5ProteinHetionet hetionet:interacts:7316-84259Inferred only
UBE2M interacts with DCUN1D5ProteinHetionet hetionet:interacts:84259-9040Inferred only
DCUN1D5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DCUN1D5 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only

Show the remaining 4

DCUN1D5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DCUN1D5 regulates positive regulation of protein neddylationBiological processgene ontology Q9BTE7|GO:2000436Inferred only
DCUN1D5 regulates regulation of cell growthBiological processgene ontology Q9BTE7|GO:0001558Inferred only
DCUN1D5 regulates regulation of protein neddylationBiological processgene ontology Q9BTE7|GO:2000434Inferred only

Other names

5 names

Resolves to: DCUN1D5

Also called: DCNL5DCUN1 domain-containing protein 5Defective in cullin neddylation protein 1-like protein 5SCCRO5Squamous cell carcinoma-related oncogene 5

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