Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8TBC4

UBA3

Protein·UNIPROT:Q8TBC4

Open in the graph

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression..

Function from UniProtKB (Q8TBC4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

36 statements

36 statements · 3 reference databases · Subject: UBA3 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

UBA3 covaries with B3GALT6ProteinHetionet hetionet:covaries:126792-9039Inferred only
UBA3 covaries with EFNB3ProteinHetionet hetionet:covaries:1949-9039Inferred only
UBA3 covaries with ERFProteinHetionet hetionet:covaries:2077-9039Inferred only
UBA3 covaries with RPL11ProteinHetionet hetionet:covaries:6135-9039Inferred only
UBA3 covaries with WNT7BProteinHetionet hetionet:covaries:7477-9039Inferred only
CHD3 interacts with UBA3ProteinHetionet hetionet:interacts:1107-9039Inferred only
NAE1 interacts with UBA3ProteinHetionet hetionet:interacts:8883-9039Inferred only
NEDD8 interacts with UBA3ProteinHetionet hetionet:interacts:4738-9039Inferred only
UBC interacts with UBA3ProteinHetionet hetionet:interacts:7316-9039Inferred only
UBA3 interacts with UBE2FProteinHetionet hetionet:interacts:140739-9039Inferred only
UBA3 interacts with UBE2MProteinHetionet hetionet:interacts:9039-9040Inferred only
UBA3 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only

Show the remaining 24

UBA3 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
UBA3 participates in C-type lectin receptors (CLRs)PathwayReactome R-HSA-5621481Inferred only
UBA3 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
UBA3 participates in CLEC7A (Dectin-1) signalingPathwayReactome R-HSA-5607764Inferred only
UBA3 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
UBA3 participates in Dectin-1 mediated noncanonical NF-kB signalingPathwayReactome R-HSA-5607761Inferred only
UBA3 participates in Dengue Virus Attachment and EntryPathwayReactome R-HSA-9918485Inferred only
UBA3 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
UBA3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
UBA3 participates in Hijack of ubiquitination by SARS CoV 2PathwayWikiPathways WP4860Inferred only
UBA3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
UBA3 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
UBA3 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
UBA3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
UBA3 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
UBA3 participates in NIK-->noncanonical NF-kB signalingPathwayReactome R-HSA-5676590Inferred only
UBA3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
UBA3 participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
UBA3 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
ATP11B decreases the expression of UBA3ProteinHetionet hetionet:regulates:23200-9039Inferred only
DHRS7 decreases the expression of UBA3ProteinHetionet hetionet:regulates:51635-9039Inferred only
MLEC decreases the expression of UBA3ProteinHetionet hetionet:regulates:9761-9039Inferred only
PPOX decreases the expression of UBA3ProteinHetionet hetionet:regulates:5498-9039Inferred only
RAE1 increases the expression of UBA3ProteinHetionet hetionet:regulates:8480-9039Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

5 names

Resolves to: UBA3

Also called: NEDD8-activating enzyme E1CUBE1CUbiquitin-activating enzyme 3Ubiquitin-activating enzyme E1CUbiquitin-like modifier-activating enzyme 3

← Every protein Find it in the graph →

or UBA6

and 160 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol

Human-GEM MAR09491CC BY 4.0Reference data