Pathway
BMAL1:CLOCK,NPAS2 activates circadian expression
As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).
REACT:R-HSA-1368108Reactome
What the reference databases state
Statements
26 statements
26 statements · 1 reference database · Subject: BMAL1:CLOCK,NPAS2 activates circadian expression · Sources: Reactome
- AVP participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- BHLHE40 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- BHLHE41 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- BMAL1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- BMAL2 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- CARM1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- CHD9 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- CLOCK participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- CREBBP participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- F7 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- HELZ2 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- KLF15 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
Show the remaining 14
- MED1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NAMPT participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NCOA1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NCOA2 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NCOA6 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NOCT participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- NPAS2 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- PPARA participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- RXRA participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- SERPINE1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- SMARCD3 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- TBL1X participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- TBL1XR1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only
- TGS1 participates in BMAL1:CLOCK,NPAS2 activates circadian expressionProteinReactome R-HSA-1368108Inferred only