Pathway
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Both Retinoid-related orphan receptors (RORA, RORB, RORC) and the heme-binding nuclear receptor NR1D1 (REV-ERBA) bind ROR response elements (RREs, ROREs) in DNA (reviewed in Duez and Staels 2008, Cox and Takahashi 2019, Laothamatas et al. 2023). RORs and NR1D1 produce opposite effects, however: RORs recruit coactivators such as EP300 (p300) and PPARGC1A to activate transcription; NR1D1 recruits the corepressor NCOR1 and the histone deacetylase HDAC3 to repress transcription.
REACT:R-HSA-9933387Reactome
What the reference databases state
Statements
24 statements
24 statements · 1 reference database · Subject: RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression · Sources: Reactome
- CARM1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- CHD9 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- CPT1A participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- CREBBP participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- EP300 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- HDAC3 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- HELZ2 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- MED1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- NCOA1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- NCOA2 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- NCOA6 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- NCOR1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
Show the remaining 12
- NR1D1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- NRIP1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- PPARA participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- PPARGC1A participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- RORA participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- RORC participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- RXRA participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- SMARCD3 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- SREBF1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- TBL1X participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- TBL1XR1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only
- TGS1 participates in RORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionProteinReactome R-HSA-9933387Inferred only