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Proteins/UNIPROT:Q8NB12
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis..
Function from UniProtKB (Q8NB12), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: SMYD1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
1 reaction
L-lysyl(4)-[histone H3]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by SMYD1 or SMYD3 or PRDM9 or SMYD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60260CC BY 4.0Reference data
1 name
Resolves to: SMYD1