Proteins/UNIPROT:P16442

ABO

ProteinUNIPROT:P16442Histo-blood group ABO system transferase

This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.

Catalyzes the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups..

Function from UniProtKB (P16442), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 5 reference databases · Subject: ABO · Sources: Hetionet, Reactome, Rhea, UniProt, WikiPathways

Order

ABO covaries with MCCProteinHetionet hetionet:covaries:28-4163Inferred only
ABO covaries with MLPHProteinHetionet hetionet:covaries:28-79083Inferred only
ABO covaries with PLPP5ProteinHetionet hetionet:covaries:28-84513Inferred only
ABO covaries with SH3YL1ProteinHetionet hetionet:covaries:26751-28Inferred only
ABO covaries with SIAEProteinHetionet hetionet:covaries:28-54414Inferred only
ABO covaries with TMEM128ProteinHetionet hetionet:covaries:28-85013Inferred only
ABO participates in ABO blood group biosynthesisPathwayReactome R-HSA-9033807Inferred only
ABO participates in Blood group systems biosynthesisPathwayReactome R-HSA-9033658Inferred only
ABO participates in Hematopoietic stem cell differentiationPathwayWikiPathways WP2849Inferred only
ABO participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ABO participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
ABO requires the cofactor Mn(2+)CompoundUniProt P16442Inferred only

Show the remaining 18

an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc derivative is a substrate of ABOCompoundRhea RHEA:84527Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc derivative is a substrate of ABOCompoundRhea RHEA:84739Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative is a substrate of ABOCompoundRhea RHEA:84519Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative is a substrate of ABOCompoundRhea RHEA:84499Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-Glc derivative is a substrate of ABOCompoundRhea RHEA:84743Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative is a substrate of ABOCompoundRhea RHEA:84507Inferred only
an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative is a substrate of ABOCompoundRhea RHEA:84523Inferred only
an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative is a substrate of ABOCompoundRhea RHEA:19021Inferred only
an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative is a substrate of ABOCompoundRhea RHEA:14349Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:84519Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:84527Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:84739Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:84743Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:14349Inferred only
UDP-alpha-D-galactose is a substrate of ABOCompoundRhea RHEA:84523Inferred only
UDP-N-acetyl-alpha-D-galactosamine is a substrate of ABOCompoundRhea RHEA:19021Inferred only
UDP-N-acetyl-alpha-D-galactosamine is a substrate of ABOCompoundRhea RHEA:84499Inferred only
UDP-N-acetyl-alpha-D-galactosamine is a substrate of ABOCompoundRhea RHEA:84507Inferred only

Reactions

9 reactions

an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative+UDP-alpha-D-galactosean alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative+UDP+hydron
Catalysed by ABO
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14349CC BY 4.0Reference data
an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative+UDP-N-acetyl-alpha-D-galactosamineCHEBI:140559+UDP+hydron
Catalysed by

Other names

12 names

Resolves to: ABO

Also called: [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]A transferaseB transferaseFucosylglycoprotein 3-alpha-galactosyltransferaseFucosylglycoprotein alpha-N-acetylgalactosaminyltransferaseGlycoprotein-fucosylgalactoside alpha-galactosyltransferaseGlycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferaseGTAGTBHisto-blood group A transferaseHisto-blood group B transferaseNAGAT

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ABO

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:19021CC BY 4.0Reference data

an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative+UDP-N-acetyl-alpha-D-galactosamineCHEBI:233961+UDP+hydron

Catalysed by ABO

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:84499CC BY 4.0Reference data

an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative+UDP-N-acetyl-alpha-D-galactosamineCHEBI:232506+UDP+hydron

Catalysed by ABO

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:84507CC BY 4.0Reference data