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Proteins/UNIPROT:P20382
[Melanin-concentrating hormone]: Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways. Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep. Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity. Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis. Antagonizes NEI-induced behavioral effects (By similarity). May also participate in spermatocyte differentiation (By similarity)..
[Neuropeptide-glutamic acid-isoleucine]: Neuropeptide that modulates stress-related neuroendocrine responses and behaviors. Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized. Reduces dopamine and DOPAC release in the ventromedial nucleus. Influences differentiation of neuronal processes and affects neurofilament protein content in vitro..
Function from UniProtKB (P20382), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 3 reference databases · Subject: PMCH · Sources: gene ontology, Hetionet, Reactome
6 names
Resolves to: PMCH