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Proteins/UNIPROT:Q9NPH5
NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release..
[Isoform 4]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in redox signaling in vascular cells. Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage..
[Isoform 3]: Lacks superoxide-generating NADPH oxidase activity..
Function from UniProtKB (Q9NPH5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
29 statements
29 statements · 6 reference databases · Subject: NOX4 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
NADPH(4-)+dioxygen+hydronhydrogen peroxide+NADP(3-)
Catalysed by FMO5 or MICAL1 or PYROXD1 or NOX4 or DUOX2 or DUOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:11260CC BY 4.0Reference data
5 names
Resolves to: NOX4
Reaction pageDirection not assertedBalanced
Rhea RHEA:63180CC BY 4.0Reference data