Pathway
Signaling by FLT3 fusion proteins
In addition to internal tandem duplications and activating point mutations, FLT3 is also subject at low frequency to translocations that generate fusion proteins. These fusion proteins occur in some chronic myeloid leukemias as well as myeloid neoplasms with eosinophilia, and generate constitutively active proteins by virtue of fusing a N-terminal partner encoding a dimerization domain with the intracellular region of FLT3 (reviewed in Reiter and Gotlib, 2017; Kazi and Roonstrand, 2019). To date, 6 fusion partner genes of FLT3 have been identified: ETV6, TRIP11, MYO18A, SPTBN1, GOLGB1 and ZMYM2.
REACT:R-HSA-9703465Reactome
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: Signaling by FLT3 fusion proteins · Sources: Reactome
- CDKN1A participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- ETV6 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- GAB2 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- GOLGB1 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- HRAS participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- MYO18A participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- NOX4 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- NRAS participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- PIK3CA participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- PIK3R1 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- PIM1 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- SOS1 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
Show the remaining 5
- SPTBN1 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- STAT5A participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- STAT5B participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- TRIP11 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only
- ZMYM2 participates in Signaling by FLT3 fusion proteinsProteinReactome R-HSA-9703465Inferred only