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Proteins/UNIPROT:P49326
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity)..
Function from UniProtKB (P49326), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 5 reference databases · Subject: FMO5 · Sources: gene ontology, Hetionet, Human-GEM, UniProt, WikiPathways
13 reactions
proton+NADPH(4-)+dioxygen+selenomethioninewater+NADP(3-)+MAM02892r
Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5
Reaction pageLeft to rightBalancedEC 1.14.13.8endoplasmic reticulum
Human-GEM MAR04009CC BY 4.0Reference data
1 paper
6 names
Resolves to: FMO5
Reaction pageLeft to rightBalancedEC 1.14.13.8cytosol
Human-GEM MAR07138CC BY 4.0Reference data
NADPH(4-)+dioxygen+MAM03053cwater+NADP(3-)+MAM03054c
Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5
Reaction pageLeft to rightBalancedEC 1.14.13.8cytosol
Human-GEM MAR09514CC BY 4.0Reference data
NADPH(4-)+dioxygen+hydronhydrogen peroxide+NADP(3-)
Catalysed by FMO5 or MICAL1 or PYROXD1 or NOX4 or DUOX2 or DUOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:11260CC BY 4.0Reference data
CHEBI:16269+NADPH(4-)+dioxygen+hydronCHEBI:17735+NADP(3-)+water
Catalysed by FMO4 or FMO3 or FMO5 or FMO1
Reaction pageLeft to rightBalanced
Rhea RHEA:24468CC BY 4.0Reference data
CHEBI:5672+NADPH(4-)+dioxygen+hydronCHEBI:87362+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54836CC BY 4.0Reference data
CHEBI:80946+NADPH(4-)+dioxygen+hydronCHEBI:87373+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54840CC BY 4.0Reference data
CHEBI:89891+NADPH(4-)+dioxygen+hydronCHEBI:88764+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54844CC BY 4.0Reference data
CHEBI:89891+NADPH(4-)+dioxygen+hydronCHEBI:89828+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54848CC BY 4.0Reference data
CHEBI:89484+NADPH(4-)+dioxygen+hydronCHEBI:89719+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54852CC BY 4.0Reference data
CHEBI:80946+NADPH(4-)+dioxygen+hydronCHEBI:86055+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54856CC BY 4.0Reference data
CHEBI:16980+NADPH(4-)+dioxygen+hydronCHEBI:138375+NADP(3-)+water
Catalysed by FMO5
Reaction pageLeft to rightBalanced
Rhea RHEA:54860CC BY 4.0Reference data