Proteins/UNIPROT:O76003

GLRX3

ProteinUNIPROT:O76003

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity..

Function from UniProtKB (O76003), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

26 statements

26 statements · 3 reference databases · Subject: GLRX3 · Sources: gene ontology, Hetionet, Reactome

Order

OR2A25 covaries with GLRX3ProteinHetionet hetionet:covaries:10539-392138Inferred only
GLRX3 interacts with ADAMTSL4ProteinHetionet hetionet:interacts:10539-54507Inferred only
GLRX3 interacts with CIAPIN1ProteinHetionet hetionet:interacts:10539-57019Inferred only
GLRX3 interacts with EFEMP2ProteinHetionet hetionet:interacts:10539-30008Inferred only
GLRX3 interacts with FRA10AC1ProteinHetionet hetionet:interacts:10539-118924Inferred only
GRN interacts with GLRX3ProteinHetionet hetionet:interacts:10539-2896Inferred only
GLRX3 interacts with HEXDProteinHetionet hetionet:interacts:10539-284004Inferred only
IKBKE interacts with GLRX3ProteinHetionet hetionet:interacts:10539-9641Inferred only
ITGA4 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-3676Inferred only
GLRX3 interacts with KRTAP4-12ProteinHetionet hetionet:interacts:10539-83755Inferred only
MAPK6 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-5597Inferred only
GLRX3 interacts with MMS19ProteinHetionet hetionet:interacts:10539-64210Inferred only

Show the remaining 14

GLRX3 interacts with NADKProteinHetionet hetionet:interacts:10539-65220Inferred only
PLSCR1 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-5359Inferred only
PRKCQ interacts with GLRX3ProteinHetionet hetionet:interacts:10539-5588Inferred only
PRKCZ interacts with GLRX3ProteinHetionet hetionet:interacts:10539-5590Inferred only
GLRX3 interacts with PRKD2ProteinHetionet hetionet:interacts:10539-25865Inferred only
SUMO2 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-6613Inferred only
UBC interacts with GLRX3ProteinHetionet hetionet:interacts:10539-7316Inferred only
VCAM1 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-7412Inferred only
ZNF23 interacts with GLRX3ProteinHetionet hetionet:interacts:10539-7571Inferred only
GLRX3 interacts with ZNF512BProteinHetionet hetionet:interacts:10539-57473Inferred only
GLRX3 participates in Iron uptake and transportPathwayReactome R-HSA-917937Inferred only
GLRX3 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
GLRX3 regulates negative regulation of cardiac muscle hypertrophyBiological processgene ontology O76003|GO:0010614Inferred only
GLRX3 regulates regulation of the force of heart contractionBiological processgene ontology O76003|GO:0002026Inferred only

Other names

6 names

Resolves to: GLRX3

Also called: PICOTPKC-interacting cousin of thioredoxinPKC-theta-interacting proteinPKCq-interacting proteinThioredoxin-like protein 2TXNL2

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