Pathway
RUNX1 regulates estrogen receptor mediated transcription
The RUNX1:CBFB complex can associate with the activated estrogen receptor alpha (ESR1) through direct interaction between RUNX1 and ESR1. The RUNX1:CBFB complex is thus involved in transcriptional regulation of estrogen responsive genes, including GPAM, KCTD6 and AXIN1. High GPAM expression correlates with better overall survival in breast cancer.
REACT:R-HSA-8931987Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: RUNX1 regulates estrogen receptor mediated transcription · Sources: Reactome
- AXIN1 participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only
- CBFB participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only
- ESR1 participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only
- GPAM participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only
- KCTD6 participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only
- RUNX1 participates in RUNX1 regulates estrogen receptor mediated transcriptionProteinReactome R-HSA-8931987Inferred only