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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O00626

CCL22

Protein·UNIPROT:O00626

Open in the graph

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Function from UniProtKB (O00626), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

27 statements

27 statements · 4 reference databases · Subject: CCL22 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CCL19 interacts with CCL22ProteinHetionet hetionet:interacts:6363-6367Inferred only
CCR4 interacts with CCL22ProteinHetionet hetionet:interacts:1233-6367Inferred only
CRYAB interacts with CCL22ProteinHetionet hetionet:interacts:1410-6367Inferred only
DPP4 interacts with CCL22ProteinHetionet hetionet:interacts:1803-6367Inferred only
GCLC interacts with CCL22ProteinHetionet hetionet:interacts:2729-6367Inferred only
CCL22 interacts with HERC3ProteinHetionet hetionet:interacts:6367-8916Inferred only
NFKB1 interacts with CCL22ProteinHetionet hetionet:interacts:4790-6367Inferred only
CCL22 interacts with VCAM1ProteinHetionet hetionet:interacts:6367-7412Inferred only
CCL22 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CCL22 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
CCL22 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCL22 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only

Show the remaining 15

CCL22 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
CCL22 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CCL22 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CCL22 participates in Interleukin-10 signalingPathwayReactome R-HSA-6783783Inferred only
CCL22 participates in Interleukin-4 and Interleukin-13 signalingPathwayReactome R-HSA-6785807Inferred only
CCL22 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CCL22 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CCL22 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCL22 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCL22 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCL22 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
CCL22 participates in T cell modulation and desmoplasia in pancreatic cancerPathwayWikiPathways WP5078Inferred only
CCL22 regulates positive regulation of cell migrationBiological processgene ontology O00626|GO:0030335Inferred only
ALMS1 increases the expression of CCL22ProteinHetionet hetionet:regulates:7840-6367Inferred only
KHDRBS1 decreases the expression of CCL22ProteinHetionet hetionet:regulates:10657-6367Inferred only

Other names

11 names

Resolves to: CCL22

Also called: ; MDC3-695-697-69CC chemokine STCP-1Macrophage-derived chemokineMDCMDC(1-69)SCYA22Small-inducible cytokine A22Stimulated T-cell chemotactic protein 1

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