Proteins/UNIPROT:Q8WXB1

METTL21A

ProteinUNIPROT:Q8WXB1Protein N-lysine methyltransferase METTL21A

Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8..

Function from UniProtKB (Q8WXB1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 4 reference databases · Subject: METTL21A · Sources: Bgee, gene ontology, Hetionet, Reactome

Order

METTL21A covaries with MRGPRGProteinHetionet hetionet:covaries:151194-386746Inferred only
METTL21A covaries with SLC25A22ProteinHetionet hetionet:covaries:151194-79751Inferred only
STX10 covaries with METTL21AProteinHetionet hetionet:covaries:151194-8677Inferred only
METTL21A is expressed in oocyteCell typeBgee ENSG00000144401Inferred only
METTL21A is expressed in secondary oocyteCell typeBgee ENSG00000144401Inferred only
HSPA1A interacts with METTL21AProteinHetionet hetionet:interacts:151194-3304Inferred only
HSPA1A interacts with METTL21AProteinHetionet hetionet:interacts:151194-3303Inferred only
HSPA5 interacts with METTL21AProteinHetionet hetionet:interacts:151194-3309Inferred only
HSPA8 interacts with METTL21AProteinHetionet hetionet:interacts:151194-3312Inferred only
ZBED8 interacts with METTL21AProteinHetionet hetionet:interacts:151194-63920Inferred only
METTL21A participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
METTL21A participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Show the remaining 2

METTL21A participates in Protein methylationPathwayReactome R-HSA-8876725Inferred only
METTL21A regulates negative regulation of protein foldingBiological processgene ontology Q8WXB1|GO:1903333Inferred only

Reactions

1 reaction

L-lysyl-[protein]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl-[protein]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by EEF1AKMT2 or SMYD5 or ATPSCKMT or ETFBKMT or EEF1AKMT1 or METTL21A or EEF1AKMT3 or EEF2KMT or ANTKMT or METTL22 or SETD2 or VCPKMT

Other names

6 names

Resolves to: METTL21A

Also called: FAM119AHCA557BHepatocellular carcinoma-associated antigen 557bHSPA lysine methyltransferaseHSPA-KMTMethyltransferase-like protein 21A

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