Proteins/UNIPROT:Q6P4H8

ATPSCKMT

ProteinUNIPROT:Q6P4H8ATP synthase subunit C lysine N-methyltransferase

Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia..

Function from UniProtKB (Q6P4H8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: ATPSCKMT · Sources: gene ontology, Hetionet

Order

ATPSCKMT covaries with AKR7A2ProteinHetionet hetionet:covaries:134145-8574Inferred only
FLYWCH2 covaries with ATPSCKMTProteinHetionet hetionet:covaries:114984-134145Inferred only
ATPSCKMT covaries with SPTBProteinHetionet hetionet:covaries:134145-6710Inferred only
ATPSCKMT covaries with TMEM273ProteinHetionet hetionet:covaries:134145-170371Inferred only
ATPSCKMT regulates positive regulation of proton-transporting ATP synthase activity, rotational mechanismBiological processgene ontology Q6P4H8|GO:1905273Inferred only
ATPSCKMT regulates positive regulation of sensory perception of painBiological processgene ontology Q6P4H8|GO:1904058Inferred only
ATPSCKMT regulates regulation of mitochondrial ATP synthesis coupled proton transportBiological processgene ontology Q6P4H8|GO:1905706Inferred only

Reactions

1 reaction

L-lysyl-[protein]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl-[protein]+3S-adenosyl-L-homocysteine+3hydron
Catalysed by EEF1AKMT2 or SMYD5 or ATPSCKMT or ETFBKMT or EEF1AKMT1 or METTL21A or EEF1AKMT3 or EEF2KMT or ANTKMT or METTL22 or SETD2 or VCPKMT

Other names

4 names

Resolves to: ATPSCKMT

Also called: FAM173BhFAM173BN-lysine methyltransferase FAM173BProtein N-lysine methyltransferase FAM173B

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