Pathway
CYP2E1 reactions
CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include acetaminophen, benzene, CCl4, halothane, ethanol and vinyl chloride. CYP2E1 contributes to oxidative stress by producing oxidising species called reactive oxygen species (ROS) which can lead to damage to mitochondria, DNA and initiate lipid peroxidation or even cell death.
REACT:R-HSA-211999Reactome
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: CYP2E1 reactions · Sources: Reactome
- CYP2A13 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2A6 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2A7 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2B6 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2C19 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2C8 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2C9 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2D6 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2E1 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2F1 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only
- CYP2S1 participates in CYP2E1 reactionsProteinReactome R-HSA-211999Inferred only