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Proteins/UNIPROT:Q1EHB4
Acts as an electroneutral and low-affinity sodium Na(+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate (By similarity). May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Probably part of D-serine transport systems involved in D-serine reabsorption at the brush border of renal proximal tubules..
Function from UniProtKB (Q1EHB4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
21 statements
21 statements · 5 reference databases · Subject: SLC5A12 · Sources: Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways
6 reactions
(S)-lactate+sodium(1+)(S)-lactate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75791CC BY 4.0Reference data
nicotinate+sodium(1+)nicotinate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75795CC BY 4.0Reference data
4 names
Resolves to: SLC5A12
pyruvate+sodium(1+)pyruvate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75799CC BY 4.0Reference data
butanoate+sodium(1+)butanoate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75803CC BY 4.0Reference data
propanoate+sodium(1+)propanoate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75807CC BY 4.0Reference data
acetoacetate+sodium(1+)acetoacetate+sodium(1+)
Transported by SLC5A12
Reaction pageDirection not assertedBalanced
Rhea RHEA:75811CC BY 4.0Reference data