Proteins/UNIPROT:Q9Y5K2

KLK4

ProteinUNIPROT:Q9Y5K2

Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity)..

Function from UniProtKB (Q9Y5K2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

amelogenesis imperfecta type 2 has a germline basis in KLK4DiseaseGenCC HGNC:6365|MONDO:0015048Inferred only
amelogenesis imperfecta type 2A1 has a germline basis in KLK4DiseaseGenCC HGNC:6365|MONDO:0008772Inferred only

Statements

12 statements

12 statements · 2 reference databases · Subject: KLK4 · Sources: Hetionet, WikiPathways

Order

ACTL6B covaries with KLK4ProteinHetionet hetionet:covaries:51412-9622Inferred only
CNBP covaries with KLK4ProteinHetionet hetionet:covaries:7555-9622Inferred only
CYP27C1 covaries with KLK4ProteinHetionet hetionet:covaries:339761-9622Inferred only
KLK4 covaries with FOXO1ProteinHetionet hetionet:covaries:2308-9622Inferred only
GPD1L covaries with KLK4ProteinHetionet hetionet:covaries:23171-9622Inferred only
KLK4 covaries with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:covaries:121504-9622Inferred only
KLK4 covaries with MAXProteinHetionet hetionet:covaries:4149-9622Inferred only
NDRG3 covaries with KLK4ProteinHetionet hetionet:covaries:57446-9622Inferred only
UBLCP1 covaries with KLK4ProteinHetionet hetionet:covaries:134510-9622Inferred only
SERPINA3 interacts with KLK4ProteinHetionet hetionet:interacts:12-9622Inferred only
SHBG interacts with KLK4ProteinHetionet hetionet:interacts:6462-9622Inferred only
KLK4 participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only

Other names

8 names

Resolves to: KLK4

Also called: EMSP1Enamel matrix serine proteinase 1Kallikrein-like protein 1KLK-L1ProstasePRSS17PSTSSerine protease 17

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