Pathway
LDL remodeling
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL, a key step in the transport of tissue cholesterol to the liver.
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As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle.
REACT:R-HSA-8964041Reactome
What the reference databases state
Statements
6 statements
6 statements · 1 reference database · Subject: LDL remodeling · Sources: Reactome
- APOB participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only
- APOF participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only
- CETP participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only
- LPA participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only
- MTTP participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only
- P4HB participates in LDL remodelingProteinReactome R-HSA-8964041Inferred only