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Proteins/UNIPROT:Q5TH69
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells..
Function from UniProtKB (Q5TH69), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
8 statements
8 statements · 2 reference databases · Subject: ARFGEF3 · Sources: gene ontology, Hetionet
5 names
Resolves to: ARFGEF3