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Proteins/UNIPROT:Q6Y288
Beta-1,3-glucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological processes. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. It starts with POFUT2, which attaches fucose via an O-glycosidic bond to a conserved serine or threonine residue. B3GLCT extends this modification by transferring a glucose molecule from UDP-glucose to the fucose..
Function from UniProtKB (Q6Y288), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
17 statements
17 statements · 4 reference databases · Subject: B3GLCT · Sources: Hetionet, Human-GEM, Reactome, Rhea
4 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
5 names
Resolves to: B3GLCT
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
3-O-(alpha-L-fucosyl)-L-seryl-[protein]+UDP-alpha-D-glucose3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein]+UDP+hydron
Catalysed by B3GLCT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:70543CC BY 4.0Reference data
3-O-(alpha-L-fucosyl)-L-threonyl-[protein]+UDP-alpha-D-glucose3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein]+UDP+hydron
Catalysed by B3GLCT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:70547CC BY 4.0Reference data