Defective ANO6 does not expose PS, PE on the platelet membrane

This Reactome event describes the defective scramblase activity of loss-of-function variants of anoctamin-6 (ANO6, also known as TMEM16F) ANO6 variants such as R419*, ANO6 W407Lfs*5 are associated with Scott syndrome, a rare inherited bleeding disorder caused by diminished PS exposure on the platelet surface (Suzuki J et al., 2010; Castoldi E et al., 2011; Boisseau P et al., 2018; Bouchaib AE et al., 2023).

Summary from Reactome (R-HSA-9853846), read 2026-09-23.