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Proteins/UNIPROT:Q96BI3
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable)..
Function from UniProtKB (Q96BI3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
62 statements
62 statements · 3 reference databases · Subject: APH1A · Sources: Hetionet, Reactome, WikiPathways
4 names
Resolves to: APH1A