Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8WW43

APH1B

Protein·UNIPROT:Q8WW43

Open in the graph

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A..

Function from UniProtKB (Q8WW43), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

52 statements

52 statements · 3 reference databases · Subject: APH1B · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

NR2F2 covaries with APH1BProteinHetionet hetionet:covaries:7026-83464Inferred only
NCSTN interacts with APH1BProteinHetionet hetionet:interacts:23385-83464Inferred only
PSEN2 interacts with APH1BProteinHetionet hetionet:interacts:5664-83464Inferred only
UBC interacts with APH1BProteinHetionet hetionet:interacts:7316-83464Inferred only
APH1B participates in Activated NOTCH1 Transmits Signal to the NucleusPathwayReactome R-HSA-2122948Inferred only
APH1B participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
APH1B participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
APH1B participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
APH1B participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
APH1B participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
APH1B participates in Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsPathwayReactome R-HSA-2894862Inferred only
APH1B participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsPathwayReactome R-HSA-2644606Inferred only

Show the remaining 40

APH1B participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
APH1B participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
APH1B participates in DiseasePathwayReactome R-HSA-1643685Inferred only
APH1B participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
APH1B participates in EPH-ephrin mediated repulsion of cellsPathwayReactome R-HSA-3928665Inferred only
APH1B participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only
APH1B participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
APH1B participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
APH1B participates in Noncanonical activation of NOTCH3PathwayReactome R-HSA-9017802Inferred only
APH1B participates in Notch signalingPathwayWikiPathways WP268Inferred only
APH1B participates in Notch signalingPathwayWikiPathways WP61Inferred only
APH1B participates in NOTCH2 Activation and Transmission of Signal to the NucleusPathwayReactome R-HSA-2979096Inferred only
APH1B participates in NOTCH3 Activation and Transmission of Signal to the NucleusPathwayReactome R-HSA-9013507Inferred only
APH1B participates in NOTCH4 Activation and Transmission of Signal to the NucleusPathwayReactome R-HSA-9013700Inferred only
APH1B participates in NRIF signals cell death from the nucleusPathwayReactome R-HSA-205043Inferred only
APH1B participates in Nuclear signaling by ERBB4PathwayReactome R-HSA-1251985Inferred only
APH1B participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
APH1B participates in Regulated proteolysis of p75NTRPathwayReactome R-HSA-193692Inferred only
APH1B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
APH1B participates in Signaling by ERBB4PathwayReactome R-HSA-1236394Inferred only
APH1B participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
APH1B participates in Signaling by NOTCH1PathwayReactome R-HSA-1980143Inferred only
APH1B participates in Signaling by NOTCH1 HD+PEST Domain Mutants in CancerPathwayReactome R-HSA-2894858Inferred only
APH1B participates in Signaling by NOTCH1 in CancerPathwayReactome R-HSA-2644603Inferred only
APH1B participates in Signaling by NOTCH1 PEST Domain Mutants in CancerPathwayReactome R-HSA-2644602Inferred only
APH1B participates in Signaling by NOTCH2PathwayReactome R-HSA-1980145Inferred only
APH1B participates in Signaling by NOTCH3PathwayReactome R-HSA-9012852Inferred only
APH1B participates in Signaling by NOTCH4PathwayReactome R-HSA-9013694Inferred only
APH1B participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
APH1B participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
APH1B participates in Signaling by TGFBR3PathwayReactome R-HSA-9839373Inferred only
APH1B participates in TGFBR3 PTM regulationPathwayReactome R-HSA-9839383Inferred only
ABAT increases the expression of APH1BProteinHetionet hetionet:regulates:18-83464Inferred only
AFF1 increases the expression of APH1BProteinHetionet hetionet:regulates:4299-83464Inferred only
DVL2 decreases the expression of APH1BProteinHetionet hetionet:regulates:1856-83464Inferred only
HOXA5 decreases the expression of APH1BProteinHetionet hetionet:regulates:3202-83464Inferred only
MACF1 increases the expression of APH1BProteinHetionet hetionet:regulates:23499-83464Inferred only
PIK3C2A increases the expression of APH1BProteinHetionet hetionet:regulates:5286-83464Inferred only
PPARA increases the expression of APH1BProteinHetionet hetionet:regulates:5465-83464Inferred only
RAD23B increases the expression of APH1BProteinHetionet hetionet:regulates:5887-83464Inferred only

Other names

4 names

Resolves to: APH1B

Also called: APH-1bAph-1betaPresenilin-stabilization factor-likePSFL

← Every protein Find it in the graph →