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Proteins/UNIPROT:Q96JK9

MAML3

Protein·UNIPROT:Q96JK9

Open in the graph

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1..

Function from UniProtKB (Q96JK9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

48 statements

48 statements · 4 reference databases · Subject: MAML3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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NFX1 interacts with MAML3ProteinHetionet hetionet:interacts:4799-55534Inferred only
NOTCH1 interacts with MAML3ProteinHetionet hetionet:interacts:4851-55534Inferred only
NOTCH2 interacts with MAML3ProteinHetionet hetionet:interacts:4853-55534Inferred only
NOTCH3 interacts with MAML3ProteinHetionet hetionet:interacts:4854-55534Inferred only
NOTCH4 interacts with MAML3ProteinHetionet hetionet:interacts:4855-55534Inferred only
RAI1 interacts with MAML3ProteinHetionet hetionet:interacts:10743-55534Inferred only
SCMH1 interacts with MAML3ProteinHetionet hetionet:interacts:22955-55534Inferred only
SUPT5H interacts with MAML3ProteinHetionet hetionet:interacts:55534-6829Inferred only
ZBTB1 interacts with MAML3ProteinHetionet hetionet:interacts:22890-55534Inferred only
ZZZ3 interacts with MAML3ProteinHetionet hetionet:interacts:26009-55534Inferred only
MAML3 participates in Canonical and non canonical Notch signalingPathwayWikiPathways WP3845Inferred only
MAML3 participates in Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsPathwayReactome R-HSA-2894862Inferred only

Show the remaining 36

MAML3 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsPathwayReactome R-HSA-2644606Inferred only
MAML3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MAML3 participates in Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)PathwayReactome R-HSA-9976102Inferred only
MAML3 participates in Differentiation of T cellsPathwayReactome R-HSA-9945266Inferred only
MAML3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
MAML3 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
MAML3 participates in Formation of paraxial mesodermPathwayReactome R-HSA-9793380Inferred only
MAML3 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
MAML3 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
MAML3 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
MAML3 participates in Notch signalingPathwayWikiPathways WP61Inferred only
MAML3 participates in Notch signalingPathwayWikiPathways WP268Inferred only
MAML3 participates in Notch-HLH transcription pathwayPathwayReactome R-HSA-350054Inferred only
MAML3 participates in NOTCH1 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-2122947Inferred only
MAML3 participates in NOTCH2 intracellular domain regulates transcriptionPathwayReactome R-HSA-2197563Inferred only
MAML3 participates in NOTCH3 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-9013508Inferred only
MAML3 participates in NOTCH4 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-9013695Inferred only
MAML3 participates in Pathways affected in adenoid cystic carcinomaPathwayWikiPathways WP3651Inferred only
MAML3 participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
MAML3 participates in Pre-NOTCH Transcription and TranslationPathwayReactome R-HSA-1912408Inferred only
MAML3 participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
MAML3 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsPathwayReactome R-HSA-210744Inferred only
MAML3 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
MAML3 participates in RUNX3 regulates NOTCH signalingPathwayReactome R-HSA-8941856Inferred only
MAML3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MAML3 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
MAML3 participates in Signaling by NOTCH1PathwayReactome R-HSA-1980143Inferred only
MAML3 participates in Signaling by NOTCH1 HD+PEST Domain Mutants in CancerPathwayReactome R-HSA-2894858Inferred only
MAML3 participates in Signaling by NOTCH1 in CancerPathwayReactome R-HSA-2644603Inferred only
MAML3 participates in Signaling by NOTCH1 PEST Domain Mutants in CancerPathwayReactome R-HSA-2644602Inferred only
MAML3 participates in Signaling by NOTCH2PathwayReactome R-HSA-1980145Inferred only
MAML3 participates in Signaling by NOTCH3PathwayReactome R-HSA-9012852Inferred only
MAML3 participates in Signaling by NOTCH4PathwayReactome R-HSA-9013694Inferred only
MAML3 participates in Transcriptional regulation by RUNX3PathwayReactome R-HSA-8878159Inferred only
MAML3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q96JK9|GO:0045944Inferred only
MAML3 regulates positive regulation of transcription of Notch receptor targetBiological processgene ontology Q96JK9|GO:0007221Inferred only

Other names

3 names

Resolves to: MAML3

Also called: KIAA1816Mam-3Mastermind-like protein 3

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