Proteins/UNIPROT:Q9ULU4

ZMYND8

ProteinUNIPROT:Q9ULU4

Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform. Suppresses breast cancer, and prostate cancer cell invasion and metastasis..

Function from UniProtKB (Q9ULU4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

neurodevelopmental disorder has a germline basis in ZMYND8DiseaseGenCC HGNC:9397|MONDO:0700092Inferred only
syndromic complex neurodevelopmental disorder has a germline basis in ZMYND8DiseaseGenCC HGNC:9397|MONDO:0800439Inferred only

Statements

33 statements

33 statements · 4 reference databases · Subject: ZMYND8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ZMYND8 covaries with CFDProteinHetionet hetionet:covaries:1675-23613Inferred only
MYO18B covaries with ZMYND8ProteinHetionet hetionet:covaries:23613-84700Inferred only
YJEFN3 covaries with ZMYND8ProteinHetionet hetionet:covaries:23613-374887Inferred only
ATN1 interacts with ZMYND8ProteinHetionet hetionet:interacts:1822-23613Inferred only
BCL6 interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-604Inferred only
CSNK1E interacts with ZMYND8ProteinHetionet hetionet:interacts:1454-23613Inferred only
ZMYND8 interacts with FHOD1ProteinHetionet hetionet:interacts:23613-29109Inferred only
ZMYND8 interacts with PBXIP1ProteinHetionet hetionet:interacts:23613-57326Inferred only
PCLAF interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-9768Inferred only
PRKCB interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-5579Inferred only
RERE interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-473Inferred only
SUMO2 interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-6613Inferred only

Show the remaining 21

UBC interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-7316Inferred only
USP7 interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-7874Inferred only
ZMYND8 interacts with ZBTB7AProteinHetionet hetionet:interacts:23613-51341Inferred only
ZFYVE9 interacts with ZMYND8ProteinHetionet hetionet:interacts:23613-9372Inferred only
ZMYND8 participates in ATP-dependent chromatin remodelersPathwayReactome R-HSA-9932444Inferred only
ZMYND8 participates in CHD chromatin remodelersPathwayReactome R-HSA-9937848Inferred only
ZMYND8 participates in CHD3, CHD4, CHD5 subfamilyPathwayReactome R-HSA-9943965Inferred only
ZMYND8 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
ZMYND8 participates in Integrated breast cancer pathwayPathwayWikiPathways WP1984Inferred only
ZMYND8 participates in Interaction of NuRD complexes with transcription factorsPathwayReactome R-HSA-9940951Inferred only
ZMYND8 participates in NuRD complex assemblyPathwayReactome R-HSA-9937850Inferred only
ZMYND8 regulates negative regulation of cell migrationBiological processgene ontology Q9ULU4|GO:0030336Inferred only
ZMYND8 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9ULU4|GO:0000122Inferred only
ZMYND8 regulates positive regulation of dendritic spine developmentBiological processgene ontology Q9ULU4|GO:0060999Inferred only
ZMYND8 regulates positive regulation of dendritic spine maintenanceBiological processgene ontology Q9ULU4|GO:1902952Inferred only
ZMYND8 regulates positive regulation of filopodium assemblyBiological processgene ontology Q9ULU4|GO:0051491Inferred only
ZMYND8 regulates positive regulation of transcription elongation by RNA polymerase IIBiological processgene ontology Q9ULU4|GO:0032968Inferred only
ZMYND8 regulates regulation of postsynaptic density protein 95 clusteringBiological processgene ontology Q9ULU4|GO:1902897Inferred only
PXN decreases the expression of ZMYND8ProteinHetionet hetionet:regulates:5829-23613Inferred only
SLC35A3 increases the expression of ZMYND8ProteinHetionet hetionet:regulates:23443-23613Inferred only
TENT4A increases the expression of ZMYND8ProteinHetionet hetionet:regulates:11044-23613Inferred only

Other names

9 names

Resolves to: ZMYND8

Also called: CTCL-associated antigen se14-3Cutaneous T-cell lymphoma-associated antigen se14-3KIAA1125kinase C-binding protein 1PRKCBP1Protein kinase C-binding protein 1RACK7Transcription coregulator ZMYND8Zinc finger MYND domain-containing protein 8

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