Pathway
Carboxyterminal post-translational modifications of tubulin
Tubulins fold into compact globular domains with less structured carboxyterminal tails. These tails vary in sequence between tubulin isoforms and are exposed on the surfaces of microtubules. They can undergo a variety of posttranslational modifications, including the attachment and removal of polyglutamate chains and in the case of alpha-tunulins the loss and reattachment of a terminal tyrosine (Tyr) residue. These modifications are associated with changes in the rigidity and stability of microtubules.
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Mutations affecting these modification processes can have severe effects on phenotype (e.g., Ikegami et al. 2007). Nevertheless, the precise molecular mechanisms by which these changes in tubulin structure modulate its functions remain unclear, so these modification processes are simply annotated here as a series of chemical transformations of tubulins.
REACT:R-HSA-8955332Reactome
What the reference databases state
Statements
41 statements
41 statements · 1 reference database · Subject: Carboxyterminal post-translational modifications of tubulin · Sources: Reactome
- AGBL2 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- AGBL4 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- AGBL5 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- AGTPBP1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- LRRC49 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- NICN1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- SVBP participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TPGS1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TPGS2 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTL participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL10 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
Show the remaining 29
- TTLL11 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL12 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL2 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL3 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL4 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL5 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL6 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL7 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL8 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TTLL9 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA1A participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA1B participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA1C participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA3C participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA3D participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA3E participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA4A participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBA8 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBAL3 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB2A participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB2B participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB3 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB4A participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB4B participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB6 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- TUBB8 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- VASH1 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only
- VASH2 participates in Carboxyterminal post-translational modifications of tubulinProteinReactome R-HSA-8955332Inferred only