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Proteins/UNIPROT:Q8NHH1
Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity)..
Function from UniProtKB (Q8NHH1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 3 reference databases · Subject: TTLL11 · Sources: Hetionet, Reactome, UniProt
2 reactions
L-glutamyl-[protein]+L-glutamate(1-)+ATP(4-)gamma-L-glutamyl-L-glutamyl-[protein]+ADP(3-)+hydrogenphosphate+hydron
Catalysed by TTLL4 or TTLL5 or TTLL7 or TTLL6 or TTLL11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60144CC BY 4.0Reference data
(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+
2 names
Resolves to: TTLL11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60148CC BY 4.0Reference data