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Proteins/UNIPROT:Q8NDL9
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation..
Function from UniProtKB (Q8NDL9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
12 statements
12 statements · 3 reference databases · Subject: AGBL5 · Sources: Hetionet, Reactome, UniProt
4 reactions
(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein]+water(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+L-glutamate(1-)
Catalysed by AGBL2 or AGBL4 or AGBL5 or AGTPBP1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60004CC BY 4.0Reference data
gamma-L-glutamyl-L-glutamyl-[protein]+waterL-glutamyl-[protein]+L-glutamate(1-)
Catalysed by AGBL5
4 names
Resolves to: AGBL5
Rhea RHEA:60152CC BY 4.0Reference data
C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin]+waterC-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin]+L-glutamate(1-)
Catalysed by AGBL4 or AGBL5 or AGTPBP1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:63792CC BY 4.0Reference data
C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin]+waterC-terminal L-alpha-aminoacyl-[tubulin]+L-glutamate(1-)
Catalysed by AGBL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:63796CC BY 4.0Reference data