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Proteins/UNIPROT:Q6EMB2
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules. Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction..
Function from UniProtKB (Q6EMB2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
12 statements
12 statements · 4 reference databases · Subject: TTLL5 · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
L-glutamyl-[protein]+L-glutamate(1-)+ATP(4-)gamma-L-glutamyl-L-glutamyl-[protein]+ADP(3-)+hydrogenphosphate+hydron
Catalysed by TTLL4 or TTLL5 or TTLL7 or TTLL6 or TTLL11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60144CC BY 4.0Reference data
(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+
5 names
Resolves to: TTLL5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60148CC BY 4.0Reference data