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Proteins/UNIPROT:Q3SXZ7
Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern..
Function from UniProtKB (Q3SXZ7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 3 reference databases · Subject: TTLL9 · Sources: Hetionet, Reactome, UniProt
1 reaction
(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+L-glutamate(1-)+ATP(4-)(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein]+ADP(3-)+hydrogenphosphate+hydron
Catalysed by TTLL1 or TTLL9 or TTLL5 or TTLL7 or TTLL6 or TTLL11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60148CC BY 4.0Reference data
2 names
Resolves to: TTLL9