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Proteins/UNIPROT:Q8N300

SVBP

Protein·UNIPROT:Q8N300

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Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation..

Function from UniProtKB (Q8N300), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

neurodevelopmental disorder with ataxia, hypotonia, and microcephaly has a germline basis in SVBPDiseaseGenCC HGNC:29204|MONDO:0032816Inferred only
syndromic intellectual disability has a germline basis in SVBPDiseaseGenCC HGNC:29204|MONDO:0000508Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: SVBP · Sources: gene ontology, Hetionet, Reactome

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CALHM6 covaries with SVBPProteinHetionet hetionet:covaries:374969-441168Inferred only
VASH1 interacts with SVBPProteinHetionet hetionet:interacts:22846-374969Inferred only
SVBP participates in Carboxyterminal post-translational modifications of tubulinPathwayReactome R-HSA-8955332Inferred only
SVBP participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SVBP participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SVBP regulates negative regulation of endothelial cell migrationBiological processgene ontology Q8N300|GO:0010596Inferred only
SVBP regulates negative regulation of protein ubiquitinationBiological processgene ontology Q8N300|GO:0031397Inferred only
SVBP regulates regulation of metallopeptidase activityBiological processgene ontology Q8N300|GO:1905048Inferred only

Other names

3 names

Resolves to: SVBP

Also called: CCDC23Coiled coil domain-containing protein 23Small vasohibin-binding protein

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