Loading the page.
Proteins/UNIPROT:Q7L8A9
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts..
Function from UniProtKB (Q7L8A9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 4 reference databases · Subject: VASH1 · Sources: Bgee, gene ontology, Hetionet, Reactome
1 reaction
C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin]+waterC-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin]+L-tyrosine
Catalysed by MATCAP1 or VASH1 or VASH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:57444CC BY 4.0Reference data
6 names
Resolves to: VASH1