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Proteins/UNIPROT:Q5U5Z8
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK..
Function from UniProtKB (Q5U5Z8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 3 reference databases · Subject: AGBL2 · Sources: Hetionet, Reactome, UniProt
1 reaction
(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein]+water(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+L-glutamate(1-)
Catalysed by AGBL2 or AGBL4 or AGBL5 or AGTPBP1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60004CC BY 4.0Reference data
4 names
Resolves to: AGBL2