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Proteins/UNIPROT:Q86V25
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation..
Function from UniProtKB (Q86V25), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
13 statements
13 statements · 3 reference databases · Subject: VASH2 · Sources: gene ontology, Hetionet, Reactome
1 reaction
C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin]+waterC-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin]+L-tyrosine
Catalysed by MATCAP1 or VASH1 or VASH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:57444CC BY 4.0Reference data
3 names
Resolves to: VASH2