Papers/PMID:42217742
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.
Brain research bulletin2026The record
6 findings · 1 compound · 6 endpoints
What it reported
How to read these marksWhat moved
6 findings
melatonin — increases reduced glutathione concentration
Evidence strength: very limited.Finding“Levels of reduced glutathione, total bilirubin, and uric acid increased in TMG comparatively with TPG (all: p < 0.001) and MG (p = 0.002; p = 0.0002; p < 0.001, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink
melatonin — increases serum uric acid
Evidence strength: very limited.Finding“Levels of reduced glutathione, total bilirubin, and uric acid increased in TMG comparatively with TPG (all: p < 0.001) and MG (p = 0.002; p = 0.0002; p < 0.001, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink
melatonin — decreases total leukocyte count
Evidence strength: very limited.Finding“There was a decrease in white blood cell, neutrophil, and lymphocyte counts in TMG comparatively with TPG (p = 0.0005; p = 0.0001; p = 0.014, respectively) and MG (p = 0.023; p = 0.007; p = 0.026, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink
melatonin — decreases fat mass
Evidence strength: very limited.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink
melatonin — decreases body mass index
Evidence strength: very limited.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink
melatonin — increases lean body mass
Evidence strength: very limited.Finding“Lean mass increased (p = 0.025) while fat mass (p = 0.0013) and body mass index (p = 0.034) decreased in TMG compared with TPG.”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:4221774210.1016/j.brainresbull.2026.111968Permalink