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pantothenic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

10 compounds within 3 steps: 2 in 1, 4 in 2, 4 in 3

Does it reach a compound?

One step

(R)-4'-phosphopantothenateReach from here →
1. Pantothenate Kinase, Mitochondrial
Catalysed by PANK2mitochondrial matrixOne of 2 routes
(R)-pantetheineReach from here →
1. (R)-pantetheine amidohydrolase
Catalysed by VNN1, VNN2cytosol

Two steps

pantetheine 4'-phosphateReach from here →
1. (R)-pantetheine amidohydrolase
2. ATP:pantothenate 4'-phosphotransferase
Catalysed by VNN1, VNN2, PANK1, PANK2 and 1 morecytosolOne of 2 routes
(R)-pantothenateReach from here →
1. Pantothenate Kinase, Mitochondrial
2. (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)
Catalysed by PANK2, PANK1, PANK3mitochondrial matrixOne of 2 routes

Three steps

CHEBI:16668Reach from here →
Catalysed by VNN1, VNN2, ADOcytosolOne of 2 routes
3'-dephospho-CoAReach from here →
Catalysed by VNN1, VNN2 and 2 more

cysteamineReach from here →

(R)-pantetheine amidohydrolase
(R)-pantetheine amidohydrolase

Catalysed by VNN1, VNN2cytosolOne of 3 routes

N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →

Pantothenate Kinase, Mitochondrial
(R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by PANK2, PPCSmitochondrial matrix, cytosolOne of 4 routes

cytosol

One of 2 routes

hypotaurineReach from here →

(R)-pantetheine amidohydrolase
(R)-pantetheine amidohydrolase
cysteamine + O2 = hypotaurine + H(+)

Catalysed by VNN1, VNN2, ADOcytosol

(R)-4'-phosphopantetheineReach from here →

Pantothenate Kinase, Mitochondrial
(R)-4'-phosphopantothenate:L-cysteine ligase
N-[(R)-4-phosphopantothenoyl]-L-cysteine + H(+) = (R)-4'-phosphopantetheine + CO2

Catalysed by PANK2, PPCS, PPCDCmitochondrial matrix, cytosol