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Reach

sphing-4-enine 1-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

120 compounds within 3 steps: 3 in 1, 20 in 2, 97 in 3

Does it reach a compound?

Three steps

2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 moreOne of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
a 1-O-alkyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine
2. phosphoethanolamine + H2O = ethanolamine + phosphate
3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
Catalysed by SGPL1, ALPL, PHOSPHO1, ENPP2
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 more
beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 5 more
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
1-O-hexadecyl-sn-glycero-3-phosphateReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 5 more
hexadecanoateReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
3. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 9 moreOne of 2 routes
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 8 more
1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 9 more
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 moreOne of 8 routes
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 more
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 more
N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
1. sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 more

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