5-amino-2-oxopentanoate

Three steps

• N-eicosanoylglycinateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by AGXT2, GATM, BAATcytosol

• N-docosanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, BAATcytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by AGXT2, SLC7A6, GLYATL1B, GLYATL1extracellular space, cytosol

• thromboxane B2Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by AGXT2, LDHA, LDHB, LDHC and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• thiamine(1+) diphosphateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by AGXT2, PDHA1, PDHB, PDHA2 and 1 moremitochondrial matrix