N(1)-acetylspermidine

Three steps

• nonadecanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by PAOX, SAT1, SAT2, CPT1A and 2 morecytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by PAOX, SAT1, SAT2cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by PAOX, SAT1, SAT2, CPT1A and 2 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of Suberylcarnitine

  Catalysed by PAOX, SAT1, SAT2, CPT1A and 2 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by PAOX, SAT1, SAT2cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by PAOX, SAT1, SAT2, CPT1A and 2 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by PAOX, SAT1, SAT2, CRAT and 1 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by PAOX, SAT1, SAT2, ACAA1 and 3 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by PAOX, SAT1, SAT2, CPT1A and 2 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by PAOX, SAT1, SAT2, SLC27A2cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by PAOX, SAT1, SAT2, ACSM4 and 5 morecytosolOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by PAOX, SAT1, SAT2, ACADM and 3 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by PAOX, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by PAOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 4 routes