1-hexadecanoylglycerone 3-phosphate

Three steps

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by GNPAT, CRAT, CROTperoxisome, endoplasmic reticulum, cytosolOne of 5 routes

• beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by AGPS, NAAA, ASAH1, ACER2 and 2 more

• (3E)-decenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by GNPAT, ACADM, ECHS1, ACAA2 and 1 moreperoxisome, cytosol, mitochondrial matrix

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate

  Catalysed by DHRS7B, AGPAT2, AGPAT3, CDS2 and 1 more

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, cytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. stearoyl-CoA 9-desaturase (palmitoyl-CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 4 routes