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Reach

a (3R)-3-hydroxyacyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

78 compounds within 3 steps: 1 in 1, 2 in 2, 75 in 3

Does it reach a compound?

Three steps

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(13Z)-docosenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(11Z)-eicosenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(15Z)-tetracosenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(17Z)-hexacosenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
heptadecanoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(9Z)-heptadecenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
nonadecanoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
a 2,3-diacyl-sn-glycerolReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 4 more
1-O-alkyl-3-acylglycerolReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 4 more
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
(13Z)-eicosenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
a 1,3-diacyl-sn-glycerolReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 3 moreOne of 2 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 4 more
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 3 more
(5Z)-tetradecenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
an N(2)-acyl-L-glutamineReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 4 more
(7Z)-hexadecenoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol
tricosanoyl-CoAReach from here →
1. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by HSD17B4, HSD17B8, ACAA1, SCP2 and 2 morecytosol

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