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Li(+)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

16 compounds within 3 steps: 1 in 1, 5 in 2, 10 in 3

Does it reach a compound?

One step

Ca(2+)Reach from here →
1. transport of Li+ (cytosol to extracellular)
Catalysed by SLC8B1extracellular space, cytosolOne of 3 routes

Two steps

L-homocarnosineReach from here →
1. transport of Li+ (cytosol to extracellular)
2. Transport of Homocarnosine
Catalysed by SLC8B1extracellular space, cytosolOne of 2 routes
potassium atomReach from here →
1. transport of Li+ (cytosol to extracellular)
2. transport of Ca2+ and K+ (cytosol to extracellular)
Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 2 moreextracellular space, cytosol
Mn(2+)Reach from here →
1. transport of Li+ (cytosol to extracellular)
2. Mn(2+)(out) + Ca(2+)(in) = Mn(2+)(in) + Ca(2+)(out)
Catalysed by SLC8B1, SLC30A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
K(+)Reach from here →
1. transport of Li+ (cytosol to extracellular)
2. Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
Zn(2+)Reach from here →
1. transport of Li+ (cytosol to extracellular)
2. Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
Catalysed by SLC8B1, SLC30A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

Three steps

CHEBI:15971Reach from here →
Catalysed by SLC8B1, CNDP1, CNDP2extracellular space, cytosol
D-aspartic acidReach from here →
Catalysed by SLC8B1, and 7 more

extracellular space, cytosol

L-cysteineReach from here →

transport of Li+ (cytosol to extracellular)
Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

seleniteReach from here →

transport of Li+ (cytosol to extracellular)
Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)

Catalysed by SLC8B1, SLC30A1, SLC39A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

chlorine(.)Reach from here →

transport of Li+ (cytosol to extracellular)
transport of Ca2+ and K+ (cytosol to extracellular)
transport of chloride (cytosol to extracellular)

Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 4 moreextracellular space, cytosolOne of 2 routes

D-aspartateReach from here →

transport of Li+ (cytosol to extracellular)
Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)
D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 7 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

L-aspartateReach from here →

transport of Li+ (cytosol to extracellular)
transport of Ca2+ and K+ (cytosol to extracellular)
transport of aspartate (cytosol to extracellular)

Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 7 moreextracellular space, cytosolOne of 3 routes

serotoninReach from here →

transport of Li+ (cytosol to extracellular)
transport of Ca2+ and K+ (cytosol to extracellular)
transport of serotonin (cytosol to extracellular)

Catalysed by SLC8B1, SLC24A1, SLC24A5, SLC24A4 and 3 moreextracellular space, cytosolOne of 2 routes

L-histidineReach from here →

transport of Li+ (cytosol to extracellular)
Transport of Homocarnosine
L-homocarnosine + H2O = 4-aminobutanoate + L-histidine

Catalysed by SLC8B1, CNDP1extracellular space, cytosol

4-aminobutanoateReach from here →

transport of Li+ (cytosol to extracellular)
Transport of Homocarnosine
Hydrolysis of homocarnosine

Catalysed by SLC8B1, CNDP1, CNDP2extracellular space, cytosolOne of 2 routes