sphingosine 1-phosphate

Three steps

• tricosanoateReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes

• 1,2-dihexadecanoyl-sn-glycerolReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 9 morecytosol

• 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
  3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 10 morecytosol

• 1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 8 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 8 routes

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Utilized Transport
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SGPL1, CRAT, CROTendoplasmic reticulum, cytosol, peroxisomeOne of 5 routes

• beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 7 morecytosol

• beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
  3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 7 morecytosol

• (3E)-decenoyl-CoAReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SGPL1, ACADM, ECHS1, ACAA2 and 1 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
  3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Fas180
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SGPL1, HADHA, ACAA2, HADHBendoplasmic reticulum, cytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. stearoyl-CoA 9-desaturase (palmitoyl-CoA)

  Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 7 moreendoplasmic reticulum, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 4 routes