acetaldehyde

Three steps

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate
  2. phosphoethanolamine + H2O = ethanolamine + phosphate
  3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

  Catalysed by ETNPPL, ALPL, PHOSPHO1, ENPP2

• 16alpha,17alpha-dihydroxyprogesteroneReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 1 morecytosol, endoplasmic reticulum

• 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosol

• 1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosol

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosolOne of 8 routes

• N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 2 morecytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Acetaldehyde:NAD+ oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 8 morecytosol, extracellular space, mitochondrial matrix