beta-D-fructose 1-phosphate

Three steps

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by ALDOB, TKFC, DERA

• dTMPReach from here →
  1. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)
  2. dATP:D-fructose 6-phosphotransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by KHK, HK1, HK2, HK3 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by ALDOB, GNPAT, AGPS

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ALDOB, AKR1A1, AKR1B1, PLA2G4AOne of 2 routes

• 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ALDOB, AKR1A1, AKR1B1, PLA2G4A

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by ALDOB, AKR1A1, AKR1B1, PLA2G4A

• 1-O-hexadecylglycerone 3-phosphateReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by ALDOB, GNPAT, AGPS

• hexadecanoateReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by ALDOB, GNPAT, AGPSOne of 2 routes