Papers/PMID:35775631
The effect of curcumin on hepatic fat content in individuals with obesity.
Diabetes, obesity & metabolism2022The record
11 findings · 1 compound · 11 endpoints · 11 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
11 findings
curcumin — no detected effect on HDL cholesterol
Evidence strength: moderate.FindingNull resultreplicated ×8“Curcumin significantly decreased triglycerides compared with placebo, but we found no effect on HDL or total cholesterol (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on waist-to-hip ratio
Evidence strength: moderate.FindingNull resultreplicated ×1“Intervention with curcumin was not associated with significant changes in BMI, waist circumference, waist–hip ratio, VAT or SAT (Table 2), or measurements from bioelectrical impedance analysis, when compared with placebo (Table S2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on ad libitum test-meal energy intake
Evidence strength: moderate.FindingNull result“Furthermore, curcumin did not affect VAS scores on palatability sensations, meal duration or ingested kcal during the ad libitum meal.”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks; meal offered after a 75 g OGTT
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on tumour necrosis factor alpha concentration
Evidence strength: limited.FindingNull resultreplicated ×3“We found no effect of curcumin on any of the measured biomarkers of inflammation (tumour necrosis factor‐alpha, interleukin [IL]‐6, IL‐8, IL‐10, interferon‐gamma, high‐sensitivity C‐reactive protein, YKL‐40) or adiponectin (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on serum adiponectin
Evidence strength: limited.FindingNull result“We found no effect of curcumin on any of the measured biomarkers of inflammation (tumour necrosis factor‐alpha, interleukin [IL]‐6, IL‐8, IL‐10, interferon‐gamma, high‐sensitivity C‐reactive protein, YKL‐40) or adiponectin (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on interleukin-6 concentration
Evidence strength: limited.FindingNull resultreplicated ×1“We found no effect of curcumin on any of the measured biomarkers of inflammation (tumour necrosis factor‐alpha, interleukin [IL]‐6, IL‐8, IL‐10, interferon‐gamma, high‐sensitivity C‐reactive protein, YKL‐40) or adiponectin (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
Show the remaining 5
curcumin — no detected effect on C-reactive protein concentration
Evidence strength: limited.FindingNull resultreplicated ×3“We found no effect of curcumin on any of the measured biomarkers of inflammation (tumour necrosis factor‐alpha, interleukin [IL]‐6, IL‐8, IL‐10, interferon‐gamma, high‐sensitivity C‐reactive protein, YKL‐40) or adiponectin (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on waist circumference
Evidence strength: limited.FindingNull result“Intervention with curcumin was not associated with significant changes in BMI, waist circumference, waist–hip ratio, VAT or SAT (Table 2), or measurements from bioelectrical impedance analysis, when compared with placebo (Table S2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on body mass index
Evidence strength: limited.FindingNull resultreplicated ×3“Intervention with curcumin was not associated with significant changes in BMI, waist circumference, waist–hip ratio, VAT or SAT (Table 2), or measurements from bioelectrical impedance analysis, when compared with placebo (Table S2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on total cholesterol (TC)
Evidence strength: limited.FindingNull resultreplicated ×3“Curcumin significantly decreased triglycerides compared with placebo, but we found no effect on HDL or total cholesterol (Table 2).”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink
curcumin — no detected effect on glycated haemoglobin (HbA1c)
Evidence strength: limited.FindingNull resultreplicated ×3“We found no statistically significant effect of curcumin on HOMA2‐IR or HbA1c when comparing with placebo.”
Quoted verbatim from The effect of curcumin on hepatic fat content in individuals with obesity.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- Meriva lecithin-formulated tablets, 1000 mg twice daily (400 mg curcuminoids) twice daily
- Population
- 37 obese non-diabetic adults, most with mild steatosis; 6 weeks
The effect of curcumin on hepatic fat content in individuals with obesity.2022PMID:3577563110.1111/dom.14804Permalink