Proteins/UNIPROT:Q8WWF5

ZNRF4

ProteinUNIPROT:Q8WWF5

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2. Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in spermatogenesis (By similarity)..

Function from UniProtKB (Q8WWF5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: ZNRF4 · Sources: gene ontology, Hetionet

Order

ZNRF4 covaries with ARRDC5ProteinHetionet hetionet:covaries:148066-645432Inferred only
CANX interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-821Inferred only
UBE2D1 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7321Inferred only
UBE2D2 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7322Inferred only
UBE2D3 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7323Inferred only
UBE2D4 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-51619Inferred only
UBE2E1 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7324Inferred only
UBE2E3 interacts with ZNRF4ProteinHetionet hetionet:interacts:10477-148066Inferred only
UBE2G2 interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7327Inferred only
UBE2N interacts with ZNRF4ProteinHetionet hetionet:interacts:148066-7334Inferred only
ZNRF4 regulates negative regulation of cell cycleBiological processgene ontology Q8WWF5|GO:0045786Inferred only
ZNRF4 regulates negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayBiological processgene ontology Q8WWF5|GO:0070433Inferred only

Other names

5 names

Resolves to: ZNRF4

Also called: NixinRING finger protein 204RING-type E3 ubiquitin transferase ZNRF4RNF204Zinc/RING finger protein 4

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